A pathogenic hemizygous synonymous variant NM_000397.4:c.483G > A (p.Lys161 =) was found in the CYBB gene related to Chronic granulomatous disease, X-linked (OMIM #306400) with XLR inheritance, that characterizes his Chronic granulomatous disease phenotype (Table 1 and Table S2). Here, CYBB is linked to chronic granulomatous disease.