CYBB and chronic granulomatous disease: Unlike the previous report SNVs, the alteration detected in the CYBB gene showed a synonymous effect (p.Lys161 =), has been classified as pathogenic by ACMG rules and Likely pathogenic by ClinVar, and is associated with a pathogenic outcome previously reported in a patient with chronic granulomatous disease (CGD) and myelodysplastic syndrome [52].