MICU1 and familial dilated cardiomyopathy: Our previous study confirmed that the downregulation of MICU1 in diabetic cardiomyocytes mediated the disorder of mitochondrial calcium uptake and promoted DCM progression, and MICU1 upregulation, via the injection of MICU1-expressing adenovirus into the myocardium of db/db mice, inhibited cardiomyocyte apoptosis and improved cardiac function [11].