Interestingly, a novel type of ER receptor, GPR30, has been reported that its activation through the selective agonist G-1 can decrease anxiety in the open field test but not in the elevated plus maze (EPM) test in female mice, whereas other ER agonist, oestradiol benzoate, had no effect on behaviours in the EPM or the open field [37]. This evidence concerns the gene GPER1 and Anxiety.