TP53 and type 2 diabetes mellitus: The serine protease inhibitor, PAI-1, which is a major target of the TGF-β1/p53 senescence signalling pathway [30], was elevated in vehicle-treated diabetic mice as compared with NDM CTRL mice; in contrast, the Dasatinib-treated group did not differ from the NDM CTRL or T2DM Vehicle groups (Fig. 6E).