Combining with gene functions, pathways, QTL regions of SCS/SCC/mastitis, and GWAS results, candidate lncRNAs and their target genes related to folate-regulated immunity of cows with subclinical mastitis were identified, such as lncRNA MSTRG.11108.1 and its target genes ICAM1, GRO1 and CXCL3. ICAM1 encodes a cell surface glycoprotein which is typically expressed on endothelial cells and the cells of the immune system [58]. The gene discussed is ICAM1; the disease is mastitis.