In the study by Cortegiani et al., performed on patients admitted to the emergency department with a diagnosis of acute respiratory failure, a CD64 index of ≥ 3.65 with a sensitivity of 94.6%, a specificity of 86.8%, and an AUC of 0.952 predicted ICU admission within 72 h. The gene discussed is FCGR1A; the disease is acute respiratory failure.