BRCA1 and breast cancer: Up until now there has been no comprehensive assessment of more than a handful of metaplastic breast cancers for germline pathogenic variants in BRCA1 or BRCA2. A previous report of exome sequencing of 30 metaplastic breast cancers with paired normal tissue did not report any mutations in BRCA1 or BRCA2 [6], although the genes were not specifically mentioned and it is possible, they excluded germline variants as they were primarily reporting somatic changes [6, 7].