ASXL1 and heart failure: Last and not least, Scolari et al. reported that cardiogenic shock patients have a higher frequency of clonal haematopoiesis (i.e., specific gene mutations, notably in TET2 and ASXL1, in haematopoietic stem cells which lead to clonal expansion) than in patients with ambulatory heart failure matched for age, sex, ejection fraction, and heart failure etiology [21].