In this context, we found that in the Cyp1a1-Ren-2 transgenic rat [38], a model of inducible ANG II-dependent form of hypertension, an impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension [38, 71–73], in agreement with the Guyton’s theory regarding the pathophysiology of the development of hypertension [74]. The gene discussed is AGT; the disease is hypertensive disorder.