In view of such evidence and the findings reported mainly by Brenner ́s and Frohlich ́s groups [16–20] we put forward the hypothesis that impairment of autoregulation of the RBF and of the pressure-natriuresis relationship precedes the onset of the decompensation phase in high-output HF, and that this impairment is augmented in ANG II-dependent hypertension. Here, AGT is linked to hydrops fetalis.