Considering the effect of BK and KKS enzymes on NGs and the effect of NG activity on KKS, we cannot decide whether NGs or their NET products induce KKS activation during HAE attacks, or, conversely, the activation of KKS attracts and activates NGs, but these results suggest an amplification loop between the activation of NGs and KKS. The gene discussed is NRGN; the disease is hereditary angioedema.