CXCR4 and P-selectin expression as well as Annexin V binding capacity were similar in NGs isolated from C1-INH-HAE patients and healthy controls; furthermore, there was no difference in spontaneous cell death as assessed by 7AAD incorporation, suggesting that clearance of NGs seems to be intact in C1-INH-HAE patients. Here, ANXA5 is linked to hereditary angioedema.