Although NGs from C1-INH-HAE patients bound slightly less Annexin V than NGs from controls (medians of fluorescence intensity (MFI) and interquartile ranges: 18.5 [6.2–39.5] vs. 38.8 [9.3–60.7]), the difference was not statistically significant (p = 0.1826, Mann–Whitney test) (Supplementary Fig. 1). The gene discussed is SERPING1; the disease is hereditary angioedema.