In addition to the 84 shared DEGs, many of the DEGs that were unique to either the DOG2 or TARGET datasets were enriched for the same IPA pathways (Supplementary Fig. 6b) including PD-1 - PD-L1 cancer immunotherapy pathway, the IL-10 signaling pathway, and IL-12 signaling and production in macrophages. This evidence concerns the gene CD274 and cancer.