Furthermore, within the DOG2 FP cohort, we see a high correlation between M1 macrophages, CD8+ T cells, activated memory CD4+ T cells, and gamma delta T-cells (Fig. 5e) which is not present in the PP group (Supplementary Fig. 7a), emblematic of an anti-tumor adaptive immune response primed by activated memory T-cells and orchestrated through M1 macrophages and highly cytotoxic CD8+ and gamma delta T-cells. This evidence concerns the gene CD8A and neoplasm.