Upon analysis of associations of genetic lesions, DDX41 displayed mutual exclusivity with RUNX1, SRSF2, STAG2 (in trend), and with adverse cytogenetic aberrations (complex karyotype, −5/del(5q)) (Supplementary Fig. S3); compared to AML with wildtype DDX41, AML with mutated DDX41 also had significantly less co-mutations (5 vs. 3; p < .001). Here, SRSF2 is linked to acute myeloid leukemia.