Of note, the ASXL1 node contained 8 of the 9 genes defining “AML with myelodysplasia-related gene mutations” and 7 of the 8 genes previously reported to define AML with antecedent MDS or myeloproliferative neoplasm [28, 34], providing further evidence for this category as a distinct AML subset. Here, ASXL1 is linked to myeloproliferative neoplasm.