The TDC sequence of R. gnavus CAG0075 had 100% identity compared with the reference TDC sequence from R. gnavus (ATCC 29149)16 and the average nucleotide identity between R. gnavus CAG0075 and R. gnavus (ATCC 29149) was 99.1%, highlighting the R. gnavus TDC is negatively correlated with the improvement of insulin sensitivity in T2D subjects. The gene discussed is INS; the disease is type 2 diabetes mellitus.