MAPT and supranuclear palsy, progressive, 1: Incorporating the scenario that FBA can assess FD and subsequent bundle atrophy, our findings reflect WM alteration patterns as a result of early tau vulnerability of the motor cortex and striatum and subsequent patterns of tau propagation to other affected cortical areas in CBS27,28,35,36 and PSP’s prominent tau pathology in the motor cortex, which occurs later but is the earliest affected compared to other cortical areas3,7,34.