MYD88 and diffuse large B-cell lymphoma: Taken together, our findings show that phosphomimetic MYD88 S257D and oncogenic L265P are equally able to propagate cell growth in DLBCL cells addicted to oncogenic MYD88 signaling, supporting the hypothesis that the oncogenic MYD88 L265P mutation exerts its oncogenic function by mimicking the activating effect of MYD88 serine 257 phosphorylation.