MYD88 and diffuse large B-cell lymphoma: In addition, we demonstrate that the MYD88 S257D mutant, which mimics constitutive S257 phosphorylation, induces strong MYD88 aggregation, IRAK1 phosphorylation, NF- κB activity and proliferation in DLBCL cells, similar to the L265P mutant, and, moreover, rescues lymphoma cells addicted to MYD88 L265P upon silencing of this oncogene.