Remarkably, MYD88 mutations are present in ~70% of primary testis lymphomas (PTLs), primary central nervous system lymphomas (PCNSLs) and primary vitreoretinal lymphomas (PVRLs) and in over 90% of Waldenström macroglobulinemia (WM) cases [2–7]. Here, MYD88 is linked to Waldenstrom macroglobulinemia.