Activating MYD88 mutations are found in 10–20% of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cases, but are rare in germinal center-like DLBCL (GCB-DLBCL) and most other B cell non-Hodgkin lymphomas [1]. Here, MYD88 is linked to diffuse large B-cell lymphoma.