Interrogation of a transcriptomic dataset (E-MTAB-2581)33 generated from samples that were enriched for CML LSCs (CD34+CD38−) and normal HSCs (CD34+CD38−), using differential gene expression analysis, revealed an upregulation of genes involved in energy metabolism, including those belonging to fatty acid metabolism (CD36), one carbon metabolism (MTHFD1L) and amino acid uptake (SLC1A5 and SLC7A5) (Fig. 1b and Supplementary Fig. S1A). Here, CD38 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.