For instance, upregulation of RACK1 expression accelerated tumorigenesis, progression, and metastasis in multiple tumors including hepatocellular carcinogenesis, oral squamous cell carcinoma [48], cervical cancer [49], and colon cancer [50], while it was reported to be a tumor suppressor gene in gastric cancer [51]. This evidence concerns the gene RACK1 and oral cavity squamous cell carcinoma.