As shown in Fig. 1A, TRIM26 expression varied in different cancer types, with higher expression in breast carcinoma, cholangiocarcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, rectal adenocarcinoma, gastric adenocarcinoma, and endometrial adenocarcinoma compared to adjacent normal tissues and decreased expression in kidney chromophobe, renal cell carcinoma, renal papillary carcinoma, and thyroid carcinoma. The gene discussed is TRIM26; the disease is hereditary clear cell renal cell carcinoma.