Here, we show a significant increase in the proportion of mesenchymal stromal cells in the TME of focal lesions and upregulation of the CXCL12-scavenger receptor CXCR7 in the patient with the strongest down-regulation of CXCL12 at the mRNA level, indicating increased supply with CXCL12 and/or uptake of the chemokine by tumor cells in focal lesions. Here, ACKR3 is linked to neoplasm.