CD274 and neoplasm: PD-1 inhibitors also enhance the efficacy through the activation of other immune cells within the TME.238 A robust anti-tumor T-cell response is induced in tumor-draining lymph nodes by blocking PD-L1-mediated inhibition of host antigen-presenting cells (APCs) at off-tumor sites.239 A further opinion has been recently expressed that the activity of ICI is not limited to TME.