IL6 and congenital rubella syndrome: The typical time to onset of CAR-T therapy-associated coagulopathy (CARAC) is often 6 to 10 days after CAR-T cell infusion and closely follows the elevation of IL-6 and other cytokines and gradually relieves as the CRS is controlled.503 CARAC, including disseminated intravascular coagulation (DIC), prolonged prothrombin time/activated partial thromboplastin time, and hypofibrinogenemia, often occurs in patients with severe CRS.603 Over half of the patients experienced thrombocytopenia or at least one abnormal coagulation parameter after CAR-T therapy.