We found that the T241-FGF2 cells formed significantly bigger tumors in Vegf-b−/− mice (Fig. 6b–d) with increased tumor angiogenesis (Fig. 6e, f), even though the T241-FGF2 cells expressed VEGF-B (Supplementary Fig. 15c, d), which might partially compensated for the loss of VEGF-B in Vegf-b deficient mice. This evidence concerns the gene FGF2 and neoplasm.