We have previously shown that VEGF-B is pro-angiogenic in mouse models of choroidal neovascularization and retinopathy of prematurity.2 Notably, these two models are, in fact, more alike vascular regression models since the neovasculature in these models eventually regresses nearly completely.46–48 Therefore, under such conditions of vascular degeneration, the previously reported anti-apoptotic effects of VEGF-B6,7 can take place and increase blood vessel survival, as such, acting pro-angiogenic (Fig. 7f). This evidence concerns the gene VEGFB and retinopathy of prematurity.