Indeed, FGF2 and FGFR1 are frequently up-regulated in tumors and play important roles in tumor angiogenesis and tumor growth.38 Therefore, in tumors with high FGF2/FGFR1 levels, VEGF-B deficiency could result in greater tumor angiogenesis and tumor growth driven by FGF2/FGFR1. The gene discussed is FGF2; the disease is neoplasm.