Indeed, multiple assays, such as EC migration/sprouting and tumor growth assays showed that when FGFR1/FGF2 were highly expressed or when FGF2 was administered, VEGF-B displayed an inhibitory effect, suggesting that under conditions of high FGFR1/FGF2 levels, VEGF-B can be anti-angiogenic by suppressing FGF2 function (Fig. 7e). Here, FGF2 is linked to neoplasm.