VEGFB and neoplasm: Different laboratories, including our own, have reported a pro-angiogenic effect of VEGF-B, mostly under conditions of tissue disintegration or degeneration, such as in myocardial infarction, heart failure or neurodegeneration.2,4–7 However, surprisingly and notwithstanding its name, many other studies have reported anti-angiogenic and anti-tumor effects of VEGF-B8–11 (Supplementary Table 1).