VEGFB and cancer: Yet, despite the poor understanding of the angiogenic effect of VEGF-B, drugs that inhibit VEGF-B together with other VEGF family members are being used in the clinic to treat patients with various neovascular diseases.14 However, in many types of cancers, such treatments failed to show benefit.14,15 It is therefore urgently imperative to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.