PITX2 and atrial fibrillation: These included known AF genes, TBX5 (PIP 0.99), NKX2-5 (0.99), PITX2 (0.99), ZFHX3 (0.85) and GATA4 (0.57), as well as TFs with roles in heart development such as HAND2 (0.87), ZEB2 (0.98), and PRRX1 (0.72).