FPGS and neoplasm: Based on RNAseq analysis, patient 6–derived tumor organoids display severe transcriptional down-regulation of FPGS expression (Van de Wetering et al, 2015; Fig S7A) and RT-qPCR analysis of patient 6–derived tumor organoids (P6T) confirms that this line displays transcriptional down-regulation of FPGS expression compared with patient 26-derived normal colon organoids (P26N; Fig S7B).