The VLDL-TG secretion rate in the fasting state [60,108] and after insulin infusion [108] is higher in obese individuals with steatosis (average TG of 11–23%) than in nonsteatotic individuals, and there is a positive correlation between VLDL-TG [60] or VLDL1-TG [108] secretion rate and hepatic TG content. The gene discussed is INS; the disease is steatosis.