PNPLA3 and Hepatic steatosis: In obese individuals with hepatic steatosis, divided into 2 groups on the basis of PNPLA3 genotype, 6 d of a hypocaloric low carbohydrate diet (<20 g/d) led to a larger decrease in hepatic TG content (-45%) in individuals with the 148M mutation than in individuals without (-18%) [106].