Further insights in this area will inform our understanding of how DNA replication initiation is deregulated during tumor development, as well as providing further mechanistic insight into how DNA replication initiation defects might underpin the development of human disease syndromes that are associated with mutations in DONSON (33, 34) and the SLD-2 orthologue RECQL4 (56, 57). The gene discussed is SLC17A5; the disease is neoplasm.