Based on these findings, we find CRP to be a poor candidate as a novel biomarker, CRELD1 and ENPP7 to be interesting novel candidates that have largely unknown roles in diabetes, and GDF15 to be a candidate with a strong association with diabetes, but which have not been identified through systematic reviews such as Abbasi et al [16] or by biomarker prioritization frameworks such as network expansion. Here, ENPP7 is linked to diabetes mellitus.