LINC00668 is upregulated in multiple cancer tissues and promotes tumorigenesis and metastasis by sponging miRNAs[46] as well as by interacting with proteins.[47] In this study, LINC00668 was significantly upregulated in exosomes secreted from Mix‐treated Caco‐2 cells and was delivered into neutrophils via IECs‐secreted exosomes, where it interacted with NE and facilitated the translocation of NE from the cytoplasm to the nucleus. This evidence concerns the gene MIXL1 and cancer.