BRAF and melanoma: When controlling for components of the melanoma brain metastases graded prognostic assessment8 in a multivariable Cox proportional hazards regression model, BRAF alteration status remained significantly associated with both OS (Figure 2C) (HR, 1.96; 95% CI, 1.08-3.55; P = .03) and CNS PFS (eFigure 2E in Supplement 2) (HR, 2.65; 95% CI, 1.54-4.57; P < .001).