BRAF and melanoma: We first analyzed samples based on consensus TCGA melanoma molecular subgroups,9 confirming the presence of NRAS (18 of 45 [40%]), BRAF (15 of 45 [33%]), NF1 (9 of 45 [20%]), and triple wildtype tumors (6 of 45 [13%]), which were mutually exclusive except for 3 cases (eFigure 1A in Supplement 2 and eTable 1 in Supplement 1).