Furthermore, patients diagnosed with advanced MTC can be treated with systemic therapies with only a minority of tumors –about 10% of RET-mutated tumors– achieving complete response with selective RET inhibitors; while the other 90% can expect a transitory partial response at best and a median progression free survival of 2–3 years with multikinase inhibitors and (probably) longer with selective RET inhibitors [4]. This evidence concerns the gene RET and medullary thyroid gland carcinoma.