Although Dynasore blocked the HIV-1 infection in Hela derived cellsand CD4+ T-cells, this drug has off target effects.38 To confirm the role of dynamin-2 in HIV-1 fusion and infection,we ectopically expressed either mCherry-Dynamin-2-WT or the mCherry-Dynamin-2-K44Amutant in TZM-bl cells. The gene discussed is CD4; the disease is HIV-1 infection.