DNM2 and infection: Inhibition of clathrin and dynamin-2-mediatedendocytosis in HeLa-derived cells reduces the efficacy of HIV-cellfusion and infection.13−16 In addition, raising endosomal and lysosomal pH tends to enhanceHIV-1 infectivity, apparently by sparing the virus from degradationin lysosomes17,18 Experimental evidence supportsproductive HIV-1 entry via endocytosis in other cell types, such asCD4+ T cells, astrocytes, and macrophages.19,20 Additional evidence came from a screen for HIV-1 host dependencefactors involved in endocytic trafficking that we carried out.