Analysis of RNA-sequencing data from the IBD Transcriptome and Metatranscriptome Meta-Analysis (TaMMA) framework (Massimino et al., 2021) revealed that, in human inflammatory bowel disease patients, DEGS2 expression was decreased in colonic and small intestinal biopsies (Massimino et al., 2021). The gene discussed is DEGS2; the disease is inflammatory bowel disease.