The expression levels of Fas, P53 and BAX in oral cancer samples were lower than those in normal samples, and the expression levels of IL-18, IL-1B, IL-6, TNF-a, c-MYC, MMP-2, MMP-9 and MMP-3 in oral cancer samples were higher than those in normal samples. The gene discussed is TP53; the disease is lip and oral cavity carcinoma.