Compared with the normal pancreatic duct epithelial cell hERT-HPNE, western blotting showed protein levels of p-IKKα/β, NF-κB, p-NF-κB, p-IκBα increased in pancreatic cancer cell lines (Figure 4C), suggesting that the NF-κB signaling pathway was upregulated in PDAC cells. The gene discussed is CHUK; the disease is pancreatic neoplasm.