Analysis of CLPP protein expression across pediatric brain tumors,49 also identified increased expression in diffuse gliomas compared with all other tumor types of the CNS, potentially highlighting its utility as a precision medicine for diffuse gliomas, solid tumors, as well as acute myeloid and lymphoblastic leukemias and hence it is currently in clinical studies in hematological malignancies (Table 1, Figure 1C). Here, CLPP is linked to hematologic disorder.