Moreover, CD180, the toll-like receptor protein RP105, has been identified to mediate the innate immune response and NF-κB activation in cooperation with TLR4.84 Interestingly, we have previously identified TLR4 as the functional target of NE in mediating aortic inflammation,18 inferring a potential role for CD180/TLR4 signaling in NE-mediated aortic inflammation and TAD development. This evidence concerns the gene NFKB1 and inflammation.