ACTA2 and stroke disorder: We also observed a nonsignificant trend toward more intraplaque hemorrhage (present: 60% versus 44%, P=0.067) and less ACTA2+ SMCs content (rank-normalized SMC content=0.06 versus 0.37, P=0.074) in plaques with high expression of GRNMAGENTA. Furthermore, these female patients presented with severe symptoms (stroke symptoms: 33% versus 19%, P=0.074; Table 2).