Similarly, GSEA of RNAseq data from a recent study (Thirimanne et al, 2022) of isogenic human colon cancer cells with wild‐type or oncogenic missense mutant FBXW7 (FBXW7R505C) identified LEF1 signalling as the most enriched gene set in FBXW7R505C cells, supporting a causal relationship. This evidence concerns the gene LEF1 and colonic neoplasm.