Interestingly, analysis of high‐grade human endometrial cancers of no specific molecular profile (NSMP) and p53 mutant subtypes and murine endometrial cancers from Ptendel and Trp53mut GEMM at experimental endpoint revealed near‐universal epithelial LEF1/Lef1 expression, irrespective of FBXW7/Fbxw7 mutation (Appendix Figs S11A and B, and S12A and B), suggesting that FBXW7/Fbxw7 wild‐type tumours may employ alternative mechanisms of Lef1 upregulation, as has been suggested by earlier studies of mouse and human tumours (Shelton et al, 2012; Ruz‐Caracuel et al, 2021). Here, LEF1 is linked to endometrial cancer.