Other biologically relevant Wnt5a-dependent processes, for example, cell-specific responses to infection (Schaale et al., 2011; Chen et al., 2017; Jati et al., 2020) or SCRIB-dependent processes – including ones directing apical-basal polarity – may be impacted by the OTULIN-SCRIB interaction and Met1-Ub homeostasis. The gene discussed is OTULIN; the disease is infection.