Another study showed that at the age of 85, the lifetime risk of AD without reference to APOE genotype was 11% to 14% for male and female, respectively, while the risk ranged from 51% to 60% for APOE ε4/ε4 carriers, and from 23% to 30% for APOE ε3/ε4 carriers, which is consistent with semi-dominant inheritance of a moderately penetrant gene (Genin et al. 2011). This evidence concerns the gene APOE and Alzheimer disease.