Consequently, this work intended to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4/CXCR7 axis on the biological functions of human trophoblast cells, providing an experimental basis for placenta previa therapy. The gene discussed is ACKR3; the disease is placenta praevia.