TNF and Parkinson disease: In the PD mouse model established using MPTP, the NO donor derivative of flurbiprofen [2-fluoro-α-methyl(1,1′-biphenyl)-4-aceticacid-4-(nitrooxy base) butyl ester] HCT1026 [55], it was found that compared with NO-free flurbiprofen, HCT1026 exhibited additional anti-inflammatory properties, which may be due to the inhibition of pro-inflammatory proteins (such as COX-2 and iNOS) and the inhibition of the release of pro-inflammatory cytokines (TNF-α) in activated macrophages.