In this study, we constructed a 15-gene risk signatures in the TCGA-BLCA cohort by univariate Cox analysis and LASSO regression analysis, and a TME signature based on the TCGA-BLCA immune microenvironment, and because the immune microenvironment affects the tumor response to immunotherapy, we combined the above two risk profiles to construct a GPR-TME signatures, and explored the value of this model in BLCA overall survival and immunotherapy. This evidence concerns the gene ALDH18A1 and bladder transitional cell carcinoma.