In the gene enrichment analysis of the most relevant signature module genes obtained from WGCNA analysis for each risk group and differential genes in ICIs-responding patients, we found that they were enriched in signaling pathways such as NF-KB signaling pathway, JAK-STAT pathway, and Wnt pathway, which suggested that the above signaling pathways might be related to bladder cancer drug resistance and recurrence. This evidence concerns the gene SOAT1 and urinary bladder cancer.