In the multifactorial Cox regression analysis, we found that genes SIGMAR1 (HR = 1.52, P < 0.001), OR2B6 (HR = 0.79, P = 0.017) and PTGER4 (HR = 0.86, P = 0.023) were independent risk factors for the prognosis of BLCA patients, OR2B6 and PTGER4 were protective factors for BLCA patients, while the opposite was true for SIGMAR1 (Figure 1c). The gene discussed is OR2B6; the disease is bladder transitional cell carcinoma.