LAMC1 secretion was associated with the formation of inflammatory CAFs in esophageal squamous cell carcinoma, and upregulation of LAMC1 expression promoted CXCL1 secretion, which stimulated inflammatory CAFs via CXCR2-pSTAT3 and thus promoted tumor progression (40). The gene discussed is CXCR2; the disease is esophageal squamous cell carcinoma.