Genes related to the p53 pathway and inflammation caused by chemokine and cytokine signaling pathways were more expressed in hepatocytes infected with HBV genotype A, while genes related to cholecystokinin receptors (CCKR) signaling map, oxidative stress response and Wnt signaling pathways were more expressed in cells infected with HBV genotype C. On the other hand, the levels of inflammatory cytokines and chemokines, including CCL2, CXCL8, CXCL9, and CXCL10, were relatively higher in HBV C genotype infection than in HBV genotype A infection. The gene discussed is CCL2; the disease is infection.