TP53 and hepatocellular carcinoma: An in vitro study determined that F141L-LHBs can induce cell cycle progression by downregulating p53 and p21 pathways and upregulating cyclin-dependent kinase 4 and cyclin A. It has been suggested that F141L-LHBs may play a critical role in the pathogenesis of HCC by inducing cell proliferation and transformation (Chen, 2018).