Recently, Wang et al have shown that silencing of ATP6AP2 expression attenuates the activation of the Wnt/β-catenin signalling pathway (Wang et al., 2019), in addition to inhibiting proliferation and inducing apoptosis of human colorectal cancer cells (Wang et al., 2019; Suda et al., 2020). The gene discussed is ATP6AP2; the disease is colorectal cancer.