Foxp3+ induced self-tolerance, so they prevent autoimmunity; Th2 are involved in neurodevelopment and GATA-3 regulates the synthesis of neurotransmitters and cell differentiation; Th1 play a role in neurological disorders (multiple sclerosis and depression) and regulate neuroinflammation together with Th17 (8). The gene discussed is GATA3; the disease is major depressive disorder.