Surprisingly, at the same time, they also found upregulated levels of miR-221, which is downregulated during adipogenesis,35 and miR-130a and miR-138, known to suppress adipogenesis by inhibiting the PPAR-γ and C/EBPα pathways, respectively,15,39 thus providing further insight into the differences between metabolic lipid storage and fat accumulation following rotator cuff tears. The gene discussed is CEBPA; the disease is rotator cuff syndrome.