COX-2 mRNA levels are reported to be overexpressed in over 80% of colorectal malignancies when compared with paired adjacent normal colorectal mucosa, implying a function for COX-2 as a possible marker for the likelihood of cancer, whereas COX-2 inhibitors could be useful in colon cancer prevention [10]. The gene discussed is PTGS2; the disease is malignant colon neoplasm.