Changes in tumor suppressor genes (e.g., APC, TP53: tumor protein 53) and oncogenes (e.g., KRAS: Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) can cause CRC, while FAP is caused by inherited germline mutations in the APC gene, which is located on chromosome six. The gene discussed is APC; the disease is Familial adenomatous polyposis.