Inrecent years different strategies have been explored to circumventthe MGMT resistance, such as the modulation of MGMT expression and/ortranscription or directly inactivating the MGMT protein.5 Different drugs with potential MGMT inhibitoryeffects have been studied and aligned with the recent investment indrug repurposing strategies for GBM, aiming to identify new uses foralready approved drugs.6 Here, MGMT is linked to glioblastoma.