SLC2A1 and neoplasm: In particular, the experimental data demonstrate that HIF-1α, a key transcription factor for adaptation to hypoxia, can regulate the expression of >100 genes downstream, including four categories of target genes that are inextricably linked to protein production and tumors: vascular endothelial growth factor (VEGF), glucose transport and glycolytic enzymes (GLUT), factors involved in tumor invasion and metastasis, and proteins related to tumor proliferation and apoptosis.42