It has been reported that HIF-1α is highly expressed in tumors such as breast, liver, bladder, cervical, colorectal, endometrial, lung, etc. 77NANOG is a protein required for the self-renewal of breast cancer stem cells (BCSCs), and high expression of NANOG in tumor tissues of breast cancer patients is correlated with poor prognosis.82 This evidence concerns the gene HIF1A and neoplasm.