It has been reported that HIF-1α is highly expressed in tumors such as breast, liver, bladder, cervical, colorectal, endometrial, lung, etc. 77NANOG is a protein required for the self-renewal of breast cancer stem cells (BCSCs), and high expression of NANOG in tumor tissues of breast cancer patients is correlated with poor prognosis.82 The gene discussed is NANOG; the disease is breast cancer.