As a specific inhibitor of histone methyltransferase G9a, BIX01294 could improve the expression of PHD2 and pVHL (von Hippel-Lindau tumor suppressor protein), thereby promoting the hydroxylation and degradation of HIF-1α, which in turn triggers cell apoptosis and inhibits the proliferation, migration, and invasion of HCC cells.162. This evidence concerns the gene HIF1A and hepatocellular carcinoma.