TEX produced by acute myelocytic leukemia (AML) cells induced widespread down-regulation of hematopoietic stem cell-supporting factors, such as CXCL12, KITL, IL-7, and IGF-1, in BMSCs and reduced their ability to support normal hematopoiesis.30 The gene discussed is CXCL12; the disease is acute myeloid leukemia.